OLEANOLIC ACID, A PROSPECTIVE PROTECTIVE AGENT AGAINST BRAIN ENERGY METABOLISM AND OXIDATIVE DYSFUNCTIONS FOLLOWING HEXAVALENT CHROMIUM EXPOSURE IN MICE

Counteracting Hexavalent Chromium-Promoted-Oxidative DNA Damage

Role of Bacillus subtilis Error Prevention Oxidized Guanine System (GO) in 1 Counteracting Hexavalent Chromium-Promoted-Oxidative DNA Damage 2 3 4 Fernando Santos-Escobar, J. Félix Gutiérrez-Corona and Mario Pedraza-Reyes 5 6 7 Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, 8 P.O. Box 187, Guanajuato, 36050, Gto. México. 9 10 11 12 13 Running Title: Rol...

Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice.

AIM To evaluate the protective effect of oleanolic acid (OA) against necrotic liver injury. METHODS Mice were pretreated with OA (200 mumol.kg-1, sc for 3 d), and subsequently administered hepatotoxicants. Liver damage was assessed by quantifying serum activities of alanine aminotransferase and iditol (sorbitol) dehydrogenase, as well as by histopathological examination. RESULTS OA pretreat...

Occupational Exposure to Hexavalent Chromium (CrVI)

Acute severe chromium poisoning after dermal exposure to hexavalent chromium.

Severe acute chromium poisoning related to dermal involvement has rarely been reported in the literature. We report a case of acute severe chromium poisoning through skin exposure as a result of a chemical burn of 15% of the body surface area and multiple organ failure after short-term exposure. Medical interventions, including mechanical ventilation, continuous venovenous hemofiltration, and p...

Histopathological and biochemical changes in rat thyroid following acute exposure to hexavalent chromium.

Chromium in hexavalent form is highly toxic and a known carcinogen, although its effects on thyroid structure and function are relatively unexplored. Workers in an industrial environment can be, at times, exposed to this form of chromium. The present study was, therefore, designed using laboratory rats as a model system to investigate the effect on thyroid structure and function following two a...